Clinical decision support · Living donors

Living KDPI Calculator

Estimate the Living Kidney Donor Profile Index (LKDPI) for a living donor–recipient pair. This model includes both donor characteristics and factors specific to the proposed pairing.

Massie et al., 2016 · Original published LKDPI model

For living donor kidney transplantation. This is the Living KDPI (LKDPI) model, not the deceased-donor KDPI calculator. It estimates risk to the transplanted kidney in the recipient, not the donor’s future health risk.

Donor & recipient information

Complete every field for the proposed pair. Results update automatically; missing information is not assumed to be normal.

Living donor characteristics

Donor age years18–100 years

Donor eGFR mL/min/1.73 m²1–200 mL/min/1.73 m²

Donor BMI kg/m²17–45 kg/m²

Donor systolic blood pressure mmHg50–250 mmHg

Donor African-American race (original model)

Donor history of cigarette use

The original 2016 equation includes a race variable, retained here to reproduce the cited model. Enter clinically assessed eGFR; the study used CKD-EPI. BMI outside 17–45 was excluded from the study. Other displayed limits are input checks, not eligibility criteria.

Donor–recipient pairing

Donor weight kg1–400 kg

Recipient weight kg1–400 kg

Are both donor and recipient male?

Is this pair ABO incompatible?

Are donor and recipient biologically unrelated?

HLA-B mismatches

HLA-DR mismatches

Use this pair’s HLA-B and HLA-DR mismatch counts (0–2 each). The study concerned adult recipients undergoing their first kidney-only transplant.

Living KDPI result

Original 2016 model · 2013 KDPI reference scale

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LKDPI score

Lower scores indicate lower modeled graft-loss risk.

Donor / recipient weight ratio

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Complete all donor and pairing fields to calculate Living KDPI.

This score is not a percentage, a predicted lifespan or a transplant eligibility decision. Negative values and scores above 100 are possible.

A score for a specific pair

ABO compatibility, HLA-B/DR mismatches, biological relationship, sex combination and weight ratio can change the score for the same donor with different recipients.

Comparable risk, not a percentage

An LKDPI of 20 represents modeled risk comparable to deceased-donor KDPI 20 on the study’s 2013 reference scale. It does not mean a 20% chance of graft loss.

Support for clinical review

The model can help compare living donor options, including paired exchange. It does not replace antibody testing, crossmatch, donor evaluation or the transplant team’s judgment.

Living donor model — clinical context required. This tool reproduces the published 2016 LKDPI equation, derived from US transplants performed in 2005–2013. Its ability to predict an individual outcome is limited. It is not the updated OPTN deceased-donor KDPI model, does not use annual KDPI reference tables, and cannot guarantee transplant success or assess donation safety.

Reference

Massie AB et al. A Risk Index for Living Donor Kidney Transplantation. American Journal of Transplantation. 2016;16:2077–2084. DOI: 10.1111/ajt.13709.

Read the study & equation ↗